Digoxin displacement

General supportive measures, including acetaminophen as an antipyretic (aspirin or other nonsteroidal antiinflammatory drugs may displace bound thyroid hormone), fluid and electrolyte replacement, sedatives, digoxin, antiarrhythmics, insulin, and antibiotics should be given as indicated. Plasmapheresis and peritoneal dialysis have been used to remove excess hormone in patients not responding to more conservative measures. 

Quinidine [HP] Increased digoxin plasma concentrations displaces digoxin from tissue binding sites. 

The following interventions are contraindicated Quinidine should not be used because it displaces digoxin from binding sites, and bretylium should not be used because it releases norepinephrine. Carotid sinus stimulation should be discouraged because it may precipitate ventricular fibrillation. 

Interaction with digoxin (by displacement from tissue binding sites and interference with its... 

Examples of changes in tissue binding are the tissue displacement of digoxin by quinidinef" and the decrease in tissue binding of digoxin in uremia.As a result in both cases, the volume of distribution of digoxin is decreased. 

The interaction of quinidine with digoxin involves displacement of digoxin from tissues. 

Highly protein bound, may displace other protein bound drugs such as digoxin or Coumadin. 

Decrease in renal clearance SDC may increase 30 0% Inhibits P-glycoprotein resulting in decrease in renal and nonrenal clearance also displacement of digoxin from tissue binding sites with decrease in the volume of distribution SDC generally increases about twofold. Decrease in renal and nonrenal clearance also... 

Quinidine Digoxin Increased digoxin levels due to decreased clearance displacement may play a role... 

There are no clinically important effects on neuromuscular blockade and, despite being highly protein-bound, there is little displacement of other highly protein-boxmd agents such as digoxin, fentanyl, lido-caine, NSAIDS, phenytoin, theophylline, or warfarin. 

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