Digoxin antiarrhythmic effects

Alee Vera (Aloe barbadensis) Uses Topically for bums, skin irritation, sunburn, wounds internally used for constipation, amenorrhea, asthma, colds Actions Multiple chemical components aloinosides inhibit H20 electrolyte reabsorption irritates colon which T peristalsis propulsion wound healing d/t i production of thromboxane A2, inhibiting bradykinin, histamine Available forms Apply gel topically 3-5/d PRN caps 100-200 mg PO hs Contra Do not use if PRG, lactating, or children <12 y Notes/SE Abd cramping, D, edema, hematuria, hypokalemia, muscle weakness, dermatitis Interactions w/ internal use T K+ loss W/ BB, corticosteroids, diuretics, licorice T effects OF antiarrhythmics, corticosteroids, digoxin, diuretics, hyperglycemias, jimsonweed EMS Assess for dehydration, electrolyte imbalance (hypokalemia), abd distress w/ internal use stimulates uterine contractions may cause spontaneous abortion... 

Answer E. Increased sympathetic activity is a major problem in hyperthyroidism and is best managed by use of beta blockers, which can offset cardiac stimulatory effects. Propranolol has an ancillary action in thyrotoxicosis in that it prevents conversion of T to Tj via its inhibition of 5 deiodinase. Amiodarone causes difficult-to-predict adverse effects on thyroid function and would not be appropriate in a patient with hyperthyroidism. Quinidine is a class lA antiarrhythmic, which is associated with tachycardia as a side effect. Digoxin is not ideal because of its complex actions on the heart, which include both inhibition and stimulation. 

Weeks CE, Conard GJ, Kvam DC, Fox JM, Chang SF, Paone RP, Lewis GP. The effect of flecainide acetate, a new antiarrhythmic, on pla a digoxin tveh.JCtinPhannacol (1986) 26, 27-31. 

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