Rifampicin Digitoxin

DIGITOXIN ANTIBIOTICS - RIFAMPICIN Plasma concentrations of digitoxin may be halved by rifampicin Due to T hepatic metabolism Watch for poor response to digitoxin... 

The metabolism of digitoxin can be increased, with resulting increasing dosage requirements, by rifampicin (289). 

Boman G, Eliasson K, Odar-Cederlof I. Acute cardiac failure during treatment with digitoxin—an interaction with rifampicin. Br J Clin Pharmacol 1980 10(l) 89-90. 

Digitoxin plasma concentrations can be reduced by rifampicin, and the dosage should be adjusted according to the serum concentration (SEDA-10, 272). 

The serum levels of digitoxin can be halved by rifampicin (rifampin). Digoxin serum levels are modestly reduced by rifampicin. 

The interaction between digitoxin and rifampicin is established and clinically important. Under-digitalisation may occur unless the digitoxin dosage is increased appropriately. Good monitoring is obviously advisable. 

Boman G, EliassonK, Odarcederldf I. Acute cardiac failure durii treatment with digitoxin - an interaction with rifampicin. BrJ Clin Pharmacol 9 (S) 10, 89-90. 

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