Digital nervous system

Gates, B. Business The Speed of Thought, Using a Digital Nervous System, Warner Books New York, 1999. 

Gates, B. (1999). Business the speed ofthought Using a digital nervous system. New York Warner Books. 

Hypoperfusion of skeletal muscles leads to fatigue, weakness, and exercise intolerance. Decreased perfusion of the central nervous system (CNS) is related to confusion, hallucinations, insomnia, and lethargy. Peripheral vasoconstriction due to SNS activity causes pallor, cool extremities, and cyanosis of the digits. Tachycardia is also common in these patients and may reflect increased SNS activity. Patients will often exhibit polyuria and nocturia. Polyuria is a result of increased release of natriuretic peptides caused by volume overload. Nocturia occurs due to increased renal perfusion as a consequence of reduced SNS renal vasoconstrictive effects at night. In chronic severe HF, unintentional weight loss can occur which leads to a syndrome of cardiac cachexia. This results from several factors, including loss of appetite, malabsorption due to gastrointestinal edema, elevated metabolic rate, and elevated levels of proinflammatory cytokines. 

Although most//ox-3.1 mutants died within a few days of birth, some survived and were fertile. These adult homozygotes were smaller than normal and showed nervous system disorders, with wavering movements and abnormal reflexes. In addition, the digits of the forelimbs were clenched and some animals had spasmodic contractions of the hindlimbs or back muscles. 

In 24 cases of Raynaud s syndrome, interferon alfa was the causative agent in 14, interferon beta in 3, and interferon gamma in 5 (32). There was no consistent delay in onset and the duration of treatment before the occurrence of symptoms ranged from 2 weeks to more than 4 years. The most severe cases were complicated by digital artery occlusion and necrosis requiring amputation. Few patients had other ischemic symptoms, such as myocardial, ophthalmic, central nervous system, or muscular manifestations. Severe Raynaud s phenomenon was also reported in a 5-year-old girl with hepatitis C (33). 

An abnormal, general elevation of sympathetic activity (termed either hyperactivity, hyper-reactivity or overreactivity) as the major cause of Raynaud s phenomenon in vibration-exposed workers has been advocated by Olsen (1990). In a recent paper, however, the same author (Olsen 1991) sees this as only one of several possible mechanisms leading to vibration-induced Raynaud s phenomenon. The active mechanism of digital artery closure mediated by central sympathetic reflexes is seen as predominant, but other active and passive mechanisms - such as abnormal adrenergic receptor activity of the smooth muscle cell or hypertrophy of vascular smooth muscle cells - are also envisaged as possible etiologic factors. An imbalance between the parasympathetic and sympathetic parts of the autonomic nervous system has been suggested to contribute to the development of VWF (Heinonen et al. 1987 Bovenzi 1990 Farkkila et al. 1990). 

Nervous system The residual effects of gaboxadol 10 mg and flurazepam 30 mg on the day after bedtime administration have been compared in a crossover, double-blind, randomized, placebo-controUed study in 25 healthy elderly subjects [16. Flurazepam significantly impaired choice reaction time, the threshold for critical flicker fusion, digit symbol substitution, and speed of compensatory tracking, but did not alter immediate or delayed word recall or the eyes-closed endpoint of the body sway test. Gaboxadol had no deleterious effects. 

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