Diflubenzuron properties

Anti-cancer properties of diflubenzuron require elucidation. The indication that one or more hydroxylated forms of diflubenzuron can regulate growth of mouse tumor cells provides a basis for further studies to identify and isolate the most active analog of this compound, and it suggests that other benzoylphenyl ureas may have similar properties (Jenkins et al. 1986). 

Diflubenzuron, registered for use in aquaculture in Europe, 3 220t Difluorobromine tetrafluoroborate, 4 144t 1,1-Difluoroethane, 13 722 physical properties of, l 778t Difluoromaleic anhydride, 15 492 Difunctional initiators, 14 252-254 23 380, 381 24 706... 

From the results it is clear that no residues were found up to the sensitivity limit of the analytical methods used. Furthermore untreated leaves were found to contain practically no radioactive material. It can be concluded that diflubenzuron after application on plants is very persistent and has no systemic properties. In other studies it was found that diflubenzuron does not permeate through the cuticular barrier into the leaves of broad bean. These studies on the fate of diflubenzuron on and in plants will be published more extensively elsewhere ( J ) Essentially the same results were obtained by Still in a study on the metabolic fate of diflubenzuron on cotton plants ( 2). In addition to metabolism, other factors might influence the fate of diflubenzuron on plants, i.e. washing off and photochemical degradation. Ruzo et al. (jQ) and Metcalf et al. (30)... 

Summarizing, diflubenzuron features mentioned in the introduction of this paper can be completed as follows The new insecticide has favourable environmental properties because it is non-persistent in soils and it has a low biological magnification. It is stable on plants and in insects, hence it has a long residual activity. It represents the best choice from the series of the benzoylphenyl ureas. It is a reversible inhibitor of chitin synthesis in insects, probably by blocking chitin synthetase. 

Selected properties of diflubenzuron are listed in Table 13.1. Diflubenzuron degradative pathways are almost entirely through cleavage between the carbonyl and amide groups of the urea bridge. Ultimately, the end products are either conjugated into predominantly water-soluble products or are acy-lated and ethylated biologically. Hydrolysis,... 

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