Differential scanning calorimetry Mettler Toledo

The differential scanning calorimetry (DSC) analysis of atorvastatin calcium, Form-I, was performed using a Mettler Toledo 821 DSC system, operating with Star software (version Solaris 2.5.1), and is shown in Fig. 1.59. 

The Glass Transition Temperature (Tg) oi the polymers was measured by differential scanning calorimetry, with a DSC-822e (Mettler-Toledo) apparatus, by using samples of pol5mier films. The samples were heated at the rate of 10°C/min under nitrogen to above 300°C. Heat flow versus temperature scans from the second heating run was plotted and used for... 

Mettler Toledo (Mettler) now markets the DSC 1 unit, but at the time that this instrumental brief was written, marketed only the DSC823 (its design is further discussed in Section 2.3, The Basics of Differential Scanning Calorimetry). For both units, Mettler now offers a two-sensor option based on a thermopile construction embedded in a chemically inert and corrosion resistant ceramic material. The sensors differ structurally in their design, although the primary difference is the number of thermocouples incorporated into each thermopile. The performance specifications are given in Table 2.8. 

Test bar characterization. The injection-molded test bars are characterized by optical microscopy and by differential scanning calorimetry (DSC). Light microscopy is carried out in a Zeiss Axioplan 2 equipped with an AxioCam camera. The specimens are cross-sections cut from the centers of the test bars. They are 10 p,m thick. Slicing is carried out at -70 °C using a rotary cryo-microtome Leica RM 2165. A Mettler-Toledo DSC 82 P is employed. Sample mass is 5.0 0.1 mg. The samples are studied under nitrogen flux, cooled to —100 °C and heated to 280 °C at a rate of 20K/min. 

Figure 1 Different types of differential scanning calorimeters, (a) Three-dimensional cylindrical calorimeter (Tian-Calvet). (b) Three-dimensional calorimeter with power compensation, (c) Two-dimensional plate-like calorimeter, (d) Scheme of a twin-chip sensor (Mettler Toledo Flash 1 DSC ) for fast scanning calorimetry.

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