Diethyltin

Triethyltin hydroxide [994-32-1] M 222.9. Treated with HCl, followed by KOH, and filtered to remove diethyltin oxide [Prince J Chem Soc 1783 7959]. 

Trimethyltin chloride reacts with carboxylic acids at 100° to give the corresponding chloride carboxylates Me2Sn(Cl)OCOR (187, 188), and diethyltin dihydride, triethyltin hydride, hexaethylditin, and bis(triethyltin) oxide have been shown to react with lead tetraacetate to give diethyltin diacetate or triethyltin acetate, as appropriate (189). 

Dimethyltin dichloride has a similar chain structure (375). In diethyltin diiodide (374), dimethyltin diisothiocyanate (376, 377), and di-chloro bis(chloromethyl)stannane (378), however, the distorted, trans-RgSnX geometry of each tin atom is completed by two bridging bonds involving the halogen or pseudohalogen atoms on the same, neighboring molecule. 

The earliest work in this field, by Cremer (466), showed that tetra-ethyltin is metabolized in vitro and in vivo (rats) to a triethyltin derivative and, later, it was further demonstrated that triethyltin compounds are converted in vitro into diethyltin derivatives (500). The latter are broken down in vivo to monoethyltins, which are eliminated from the body within a short time (501). Other trialkyltins appear to behave similarly (500). 

Since the discovery of the anticancer and antitumor activity of platinum complexes, there has been an effort to identify organic complexes of other metals that possess similar activities. Gielen and coworkers39 state that the antitumor activities of the di- -butyltin(TV) and diethyltin(IV) fluorobenzoates (FQdECOO SnlG and (FC6H4-C00SnR2)402, R = Et, Bu are satisfactory. 

Since the tragic human exposure to diethyltin salts for the therapy of an infectious skin disease by Staphylococcus in France in the 1950s, the toxic and biochemical effects of many of these derivatives have been explored. Di- and tri-ethyltin salts have been demonstrated to have pronounced effects on intermediary metabolism in brain and liver. These effects have been suggested to be due to inhibition of the mitochondrial functions9,27. 

Identification and quantitation of methyltin hydrides were achieved by selected ion monitoring [99]. Major ions representative of the three methylstannanes and the internal standard (diethyltin) were nominal, mle 116, 118, 120, 133, 135, 148, 150 and 165. 

Triethyltin Oral administration of a French medication (Stalinon, containing diethyltin diiodide and isolinoleic esters) for treatment of... 

Diethyl stannic dichloride, AD32 Diethyl(2-th ioethyl) amine, A139 Diethyltin dichloride, AD32... 

Triphenyl- and tributyltin compounds have strongly biocidal properties and are employed in some agricultural fungicides and wood preservatives42. Other possible applications include disinfectants for use in hospitals and for the eradication of snails that transmit bilharzia. However, these compounds are potentially hazardous because of the ease with which they inhibit oxidative phosphorylation in man. Oral administration of diethyltin diiodide as a treatment for boils led to many deaths43. ... 

SYNS DIAETHYLZINNDICHLORID (GERMAN) DICHLORODIETHYLTIN DIETHYLDICHLORO-STANNANE DIETHYLSTANNYL DICHLORIDE DIETHYLTIN CHLORIDE DIETHYLTIN DICHLORIDE... 

SYNS DIETHYLBIS(l-OXOOCTYL)OXY)STANNANE DIETHYLTIN DICAPRYLATE DIETHYLTIN DIOCTANOATE... 

SYNS DIETHYLSTANNIUMDIIODIDE DIETHYLSTANNIUMDIJODID (GERMAN) DIETHYLTIN DIIODIDE TIN, DIETHYL-, DIIODIDE... 

A similar series of complex investigations was performed on diethyltin(IV) complexes of A -D-gluconylamino acid ligands. The potentiometric equilibrium measurements led to the concentration distribution curves in Fig. 3. 

Figure 3 Concentration distribution curves of the system diethyltin(lV) - iV-D-gluconylglycine at a metal to ligand ratio of 1 10, [Et2Sn2+] = 1.0x10 moldm 3.

The 13c-NMR spectrum of the iV-D-gluconyl-p-alanine complex, soluble in water at pH 10, reflected a different structure. The differences in the chemical shifts of the ligand C atoms in the presence and absence of diethyltin(IV) are small, but the signals of the carboxylate and three other C atoms (C(3), C(4) and C(5)) which carry alcoholic OH groups are broadened, which is characteristic of complexes with an intermediate ligand exchange rate. The above... 

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