Diethylamine diethyldithiocarbamate

Tellurium diethyldithiocarbamate [20941-65-5], [(C2H5)2NC(S)S]4Te, is made by the reaction of diethylamine, carbon disulfide, and tellurium dioxide in an alcoholic solution. 

Following a single oral dose of 250 mg to 15 subjects, mean peak plasma concentrations of 0.38 pg/ml of disulfiram, 0.77 pg/ml of diethyldithiocarbamic acid, 0.30 pg/ml of methyl diethyldithiocarbamate, and 1.7 pg/ml of diethylamine were attained in about 9 hours a mean peak plasma concentration of 22 pg/ml of carbon disulphide was reported at 6 hours there was considerable intersubject variability in the plasma concentrations (M. D. Faiman etai, Clin. Pharmac. Ther., 1984, 36, 520-526). 

Thiram is absorbed via the skin, mucous membranes, respiratory, and gastrointestinal tracts. Thiram is rapidly absorbed from the gastrointestinal tract. Thiram and other dimethyldithiocarbamates are metabolized to diethyldithiocarbamic (DDC) acid, diethylamine, and carbon disulfide. DDC is rapidly absorbed by the gastrointestinal tract and further metabolized by hepatic enzymes. A portion of the acid is excreted unchanged or as glucuronide conjugate. Further metabolism can result in the formation of dimethylamine and carbon disulfide residues. 

Sodium diethyldithiocarbamate decomposes in acid solution, forming diethylamine and carbon disulphide ... 

Carbon Disulfide in the Atmosphere. The pulp and paper industry often causes pollution of the atmosphere with carbon disulfide. To determine CS2 in the atmosphere, a gaseous sample from a chimney, for instance, is drawn into a vessel containing diethylamine solution in 96% ethanol which converts the carbon disulfide into diethyldithiocarbamate while still at the site. The solution does not deteriorate with time, so the sample vessel can be left in place for several days to enrich the sample in CSg. In the laboratory, the sample is diluted with a lithium-chloride solution and a polarogram recorded. 

Carbon disulfide, for example, can be determined by dpp in water, in concentrations as low as 1 / g CS2/I, using a purging step to preconcentrate the CS2 in ethanol/diethylamine with the subsequent formation of diethyldithiocarbamate. The polarographic procedure is substantially more sensitive than other reported methods. ... 

Procedure. Boil the fibre in 30 per cent sulphuric acid and trap the carbon disulphide set free in a U-tube (Fig. 40) filled with a 1 per cent ethanolic solution of diethylamine. Trap the hydrogen sulphide in a tube containing cadmium acetate solution, incorporated between the sulphuric acid and sample and the trapping U-tube. Determine the diethyldithiocarbamate formed polarographically, using the anodic wave of the mercury salt formation, as in the determination of carbon disulphide given in Chapter VI. 

Diethylamine reacts with carbon disulfide and sodium hydroxide to produce sodium diethyldithiocarbamate (NaDEC) to subsequently yield tellurium diethyldithiocarba-mate (TeDEC) rubber accelerator. 

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