Diethyl N-benzylideneaminomethylphosphonate

Diethyl ami nomethylphosphonate Phosphonic acid, (aminomethyl)-, diethyl ester (50917-72-1 ), 65, 119 DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PHOSPHONIC ACID, [[(PHENYLM THYLENE)AMINO]METHYL]-, DIETHYL ESTER ... 

Steven K. Davidsen, Gerald W. Phi 11ips, and Stephen F. Martin 119 GEMINAL ACYLATION-ALKYLATION AT A CARBONYL CENTER USING DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PREPARATION OF 2-METHYL-2-PHENYL-4-PENTENAL... 

Johnson. N-Bromomethylphthallmide has also been prepared by treatment of H-hydroxymethylphthallmlde with phosphorus tribromide.5 The procedures for the syntheses of the phosphorates 3 and 4 represent modifications of those described by Yamauchi and co-workers.5 Two other routes to 4 have recently been reported by Gross and co-workers.5 Rateliffe and Christensen have also recorded the preparation of diethyl N-benzylideneaminomethylphosphonate (5) by the condensation of benzaldehyde with 4 under virtually identical conditions as detailed herein, but their route to 4 was completely different.6 The submitters have found that the present method for the syntheses of 2-5 gives reproducibly higher yields and is more reliable and convenient than those alternative procedures. 

Diethyl N-benzylideneaminomethylphosphonate (5) has been previously employed as an intermediate in the synthesis of B-lactam antibiotics6 and as a reagent for the homologation of aldehydes and ketones via intermediate 2-azadienesJ Other derivatives of dialkyl am1nom thylphoxphon t. s hav alio... 

Diethyl N-benzylideneaminomethylphosphonate Phosphonic acid, C[(phenylmethylene)amino]methyl]-, diethyl ester (9) (50917-73-2)... 

DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PHOSPHONIC ACID, [[(PHENYLMETHYLENE)AMINO]METHYL)-, DIETHYL ESTER ... 

Diethyl N-benzylideneaminomethylphosphonate Phosphonic acid, [[(phenylmethylene)amino]methyl]-, diethyl ester (9) (50917-73-2) 2-Methyl-2-phenyl-4-pentenal 4-Pentenal, 2-methyl-2-phenyl- (8,9) (24401-39-6)... 

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