Diethyl-3-methyl-2-butenyl malonate

Diethyl-3-methyl-2-butenyl malonate Manufacturing Process... 

Butyl- and 3-(3-methyl-2-buteny l)-2-hydroxy-4//-pyrido[ 1,2-a]py-rimidin-4-ones were prepared in the reaction of 2-aminopyridine and diethyl 2-butyl- and 2-(3-methyl-2-butenyl)malonates, respectively (84MI-14 89MI16). 

The carbopalladation is extended to homoallylic amines and sulfides[466. Treatment of 4-dimethylamino-l-butene (518) with diethyl malonate and Li2PdCl4 in THF at room temperature leads to the oily carbopalladated complex 519, hydrogenation of which affords diethyl 4-(dimethylamino) butylmalonate (520) in an overall yield of 91%. Similarly, isopropyl 3-butenyl sulfide (521) is carbopalladated with methyl cyclopentanonecarboxylate and Li2PdCl4. Reduction of the complex affords the alkylated keto ester 522 in 96% yield. Thus functionalization of alkenes is possible by this method. 

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