Diethyl aminomethylphosphonate: Phosphonic acid,

Diethyl aminomethylphosphonate Phosphonic acid, (aminoraethyl)-, diethyl ester (9) (50917-72-1)... 

Diethyl aminomethylphosphonate Phosphonic acid, (aminomethyl)-, diethyl ester (50917-72-1), 65, 119 DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PHOSPHONIC ACID, [[(PHENYLMETHYLENE)AMINO]METHYL].-, DIETHYL ESTER ... 

Michael addition of metallated camphor derivatives of diethyl aminomethylphosphonate to diethyl vinylphosphonate followed by hydrolysis with 90% aqueous AcOH leads in 73% yield and high diastereoselectivity to tetraethyl A-acetyl 2-amino-l,3-propylenediphosphonate, a phosphonic analogue of glutaric acid (Scheme 8.8V). No racemization occurs under the hydrolysis conditions Similarly, methyl acrylate, after hydrolysis of diastereomerically pure adduct, leads to the phosphonic analogue of pyroglutamic acid further reduced with I.iBlI,/BF. t,() to the phosphoproline diethylester in 61% yield (Scheme 8.87). ... 

Alkylation of chiral imidazolidinones with 1,3-dibromopropane in the presence of LDA followed by a second condensation with the anion of the (-)-camphor imine of diethyl aminomethylphosphonate gives access to the phosphonic acid analogues of diaminopimelic acid (DAP) as pure diastereomers. ... 

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