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Diet-induced bone loss

Compston, J. E., Laskey, M. A., Croucher, P. 1., Coxon, A., and Kreitzman, S. (1992). Effect of diet-induced weight loss on total body bone mass. Clin. Sci. (Land.) 82, 429 32. [Pg.332]

Arjmandi et al., 1998a,b 95 d old OVX rats 35 d casein diet after OVX, then 65 d soy protein with isoflavones (9 mg/d) No significant effect of soy protein in reversal of bone loss, assessed by BMD. Soy induced femoral lGF-1 mRNA and some increases in bone turnover markers... [Pg.94]

Vitamin D is a fat soluble vitamin related to cholesterol. In the skin, sunlight spontaneously oxidizes cholesterol to 7-dehydrocholesterol. 7-Dehydrocholesterol spontaneously isomerizes to cholecalciferol (vitamin D3), which is oxidized in the liver to 25-hydroxy cholecalciferol and, under the influence of PTH in the kidney, to 1,25-dihy-droxy cholecalciferol (calcitriol), the active form of vitamin D. Vitamin D induces the expression of calcium ion transport proteins (calbindins) in intestinal epithelium, osteoclasts, and osteoblasts. Calbindins and transient receptor potential channels (TRPV) are responsible for the uptake of calcium from the diet. In children, the absence of sunlight provokes a deficiency of vitamin D, causing an absence of calbindins and inadequate blood calcium levels. Osteoid tissue cannot calcify, causing skeletal deformities (rickets). In the elderly, there is a loss of intestinal TRPV receptors and decreased calbindin expression by vitamin D. In both cases, the resultant low blood calcium levels cause poor mineralization during bone remodeling (osteomalacia). Rickets is the childhood expression of osteomalacia. Osteoclast activity is normal but the bone does not properly mineralize. In osteoporosis, the bone is properly mineralized but osteoclasts are overly active. [Pg.171]


See other pages where Diet-induced bone loss is mentioned: [Pg.293]    [Pg.293]    [Pg.282]    [Pg.35]    [Pg.187]    [Pg.444]    [Pg.282]    [Pg.522]    [Pg.175]    [Pg.178]    [Pg.6]    [Pg.88]    [Pg.246]    [Pg.1467]    [Pg.1467]    [Pg.644]    [Pg.332]    [Pg.823]    [Pg.594]    [Pg.331]    [Pg.525]    [Pg.454]   
See also in sourсe #XX -- [ Pg.293 ]




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