Didanosine Trimethoprim

Drugs that may affect valganciclovir include didanosine, imipenem-cilastin, nephrotoxic drugs, probenecid, trimethoprim, zalcitabine, and zidovudine. Drugs that may be affected by valganciclovir include cytotoxic drugs, didanosine, and zidovudine. 

Levels of ganciclovir may rise in patients concurrently taking probenecid or trimethoprim. Concurrent use of ganciclovir with didanosine may result in increased levels of didanosine. 

Noninterfering acetaminophen, amphotericin B, brotizolam, ceftazidime, ciprofloxacin, codeine, diclofenac, didanosine, domperidone, fluoxetine, foscarnet, gangiclovir, methadone, metoclopramide, mianserin, nystatin, pyrimethamine, ranitidine, sulfamethoxazole, temazepam, trimethoprim, zidovudine... 

The modest decreases in trimethoprim and sulfamethoxazole levels, and moderate increases in didanosine levels caused by cidofovir are considered unlikely to be clinically relevant because of the infrequent dosing schedule of cidofovir/probenecid. No dose adjustments are considered necessary. ... 

Cidofovir with probenecid modestly decreased levels of trimethoprim and sulfamethoxazole (co-trimoxazole), and caused moderate increases in didanosine levels, but did not alter fluconazole pharmacokinetics. None of these drugs altered cidofovir pharmacokinetics. 

Trimethoprim, both aione and as co-trimoxazoie (trimethoprim with suifamethoxazoie) reduces the renai ciearance of iamivu-dine, zaicitabine and zidovudine, and therefore raises their pias-ma ieveis. However, the extent of the interaction does not usuaily appear to be ciinicaiiy significant in patients with normal renal function. No clinically significant adverse pharmacokinetic interaction occurs if didanosine is given with co-trimoxazole or trimethoprim. 

SrinivasNR,Kni5)pCA,BatteigerB, Smith R BarbhaiyaRH. A pharmacokinetic interaction study of didanosine coadministered with trimethoprim and/o sulphamethoxazole in HIV seropositive asymptomatic male patients. BrJ CUn Pharmacol (199 41,207-15. 

Simultaneous didanosine, folic acid, ganciclovir, lamivudine, nevirapine, pyrazinamide, ranitidine, rifampin, stavudine, sulfamethoxazole, trimethoprim, zidovudine Noninterfering adefovir, amprenavir, delavirdine, efavirenz, fluconazole, indinavir, itraconazole, methadone, nelfinavir, oxazepam, pyrimethamine, rifampin, ritonavir, saquinavir, zalcitabine... 

Noninterfering acetaminophen, amineptine, amphotericin B, aspirin, bromazepam, buspirone, citalopram, clobazam, diazepam, didanosine, fluconazole, flunitrazepam, flu-voxamine, hydroxyitraconazole, isoniazid, itraconazole, lamivudine, loprazolam, lora-zepam, metronidazole, minalcipram, nordiazepam, omeprazole, paroxetine, pyrimethamine, rifampin, sertraline, stavudine, sulfadiazine, trimethoprim, venlafaxine, zal-citabine, zidovudine, zolpidem, zopiclone... 

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