Imipenem-cilastin

Drugs that may affect valganciclovir include didanosine, imipenem-cilastin, nephrotoxic drugs, probenecid, trimethoprim, zalcitabine, and zidovudine. Drugs that may be affected by valganciclovir include cytotoxic drugs, didanosine, and zidovudine. 

Newcomb, H.W. Hill, E.M. McCarthy, I.D. Mostow, S.R. Imipenem-cilastin dosing intervention program by pharmacists. Am. J. Hosp. Pharm. 1992, 49, 1133-1135. 

Combination therapy is often used when dealing with infections caused by both aerobic and anaerobic bacteria [50,80]. Combination of metronidazole with either gentamicin or ciprofloxacin appeared to be effective in preventing infection of abdominal trauma [101] when combined with ciprofloxacin, metronidazole was affective as a preoperative antibiotic in colorectal surgery and appeared equal in efficacy to impipenem/cilastin for the treatment of complicated intraabdominal infections [103]. Combination therapy is not always indicated for the treatment of polymicrobial infections. New antibiotics, whose spectrum includes multiple classes of microorganisms (e.g., imipenem), may often preclude combination therapy. 

Pustular drug eruptions due to penicillin (195), amoxicillin (196), ampicillin (197), bacampicillin (198), cefazo-hn (199,200), cefradine (201), cefalexin (202), cefaclor (203), or imipenem -I- cilastin (204) seem to form a distinct chnical entity that has to be differentiated from pustular psoriasis, which can be drug-induced as well (204). A history of drug exposure, rapid disappearance of the eruption after the drug is stopped, and eosinophils in the inflammatory infiltrate argue in favor of pustular drug eruptions. 

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