Diclofenac Electrodes

In recent years, many different ion-selective electrodes were developed for determination of diclofenac in pharmaceutical preparations. The main parameters of the obtained electrodes, their membrane contents and the type of pharmaceutical samples to which they were applied, are presented in Table 8.2. 

Development of ion-selective electrodes for pharmaceutical analysis is still an actual, progressing scientific direction. Currently, the most frequently developed types of electrodes are those with a microporous matrix (PVC) and mobile active centers. The goal is to reach the best parameters, in particular the selectivity and the longest lifetime. It would allow application of these devices in industrial practice. There are many options to choose from, both in terms of the electrode design and the modifications of the membrane. Solid-state electrodes are becoming more and more popular. In the future, there can be much development in the field of sensors for determination of drugs, based on conductive polymers, which are currently rare. 

Polymer membrane composition -Slope [mV decade -Linearity range [molL- l -Response time [s] -Life time -pH range Selectivity Pharmaceutical samples, Recovery [%] orRSD [%] Ref. 

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Oumada et al. [148] described a new chromatographic method for determining the aqueous pKa of dmg compounds that are sparingly soluble in water. The method uses a rigorous intersolvent pH scale in a mobile phase consisting of a mixture of aqueous buffer and methanol. A glass electrode, previously standardized with common aqueous buffers, was used to measure pH online. The apparent ionization constants were corrected to a zero-cosolvent pH scale. Six sparingly soluble nonsteroidal antiinflammatory weak acids (diclofenac, flurbiprofen, naproxen, ibu-profen, butibufen, fenbufen) were used successfully to illustrate the new technique. 

Z. Kormosh, I. Hunka, Y. Bazel, Potentiometric determination of diclofenac in pharmaceutical formulation by membrane electrode based on ion associate with base dye, Chinese... 

Z. Kormosh, I. Hunka, Preparation and study of a diclofenac selective membrane electrode. Analytical and Bioanalytical Electrochemistry, 1 (1), 27-yj, 2009. 

Goyal RN, Chatterjee S, Agrawal B (2010) Electiochemical investigations of diclofenac at edge plane pyrolytic graphite electrode and its determination in hrrman rrrine. Sens Actrrators B Chem 145 743-748... 

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