Diclofenac chemical structure

NSAIDs are of diverse chemical structures salicylates (aspirin, sulphasalazine), indole acetic acids (indomethacin, etodolac), heteroaryl acetic acids (diclofenac), arylpropionic acids (ibuprofen, naproxen), anthranilic acids (mefenamic acid) and enolic acids (piroxicam, meloxicam). 

Morpholinoalkyl esters (see Figure 16.1 for chemical structures) ofthe potent nonsteroidal anti-inLammatory agent, diclofenac, were prepared and characterized regarding solubility and hydrolysis reaction rates (Tammara et al., 1994). The alkyl group provides a spacer between the carboxylic acid... 

FIGURE 16.1 Chemical structure of water-soluble morpholinoalkyl ester prodrugs of diclofenac. The subscript equals 2, 3, or 4. 

Chemical Structures diclofenac sodium topical gel (Figure52.1) molecularformula Cj HjjjCljN-NaO diclofenac epolamine patch (Figure 52.2) molecular formula C jH CljN Oj... 

Chemistry diclofenac is a phenylacetic acid derivative its chemical name is 2-(2-(2,6-dichlo-rophenylamino)phenyl)acetic acid Chemical Structure see Figure 53.1 Molecular Formula Cj H jCl NO ... 

Oxazolidin-5-ones (11.110) are structurally related to oxazolidines, combining the motifs of a lactone and an O-Mannich base. These derivatives have already been discussed in Sect. 8.7.5. However, they serve here as a transition to [3,1 ]benzoxazepin-4-ones as an example of potential prodrugs. Thus, [3,l]benzoxazepin-4-one derivatives (11.111, R = H or Me, R = H, Me, Et, or Ph) were prepared from diclofenac (11.112) [137]. These prodrugs were stable for at least a few hours in simulated gastric juice, but, when administered to rats elicited an anti-inflammatory response comparable to that of diclofenac. One compound (11.111, R = Me, R = Et) was even more active than diclofenac without producing the gastric mucosal injury (ulcers) caused in all rats by diclofenac itself. Here again, there was no indication of whether the mechanism of hydrolysis is chemical or enzymatic. 

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