Diazotization, of 3,5-dichloro-2-aminobenzoic acid

B. Diazotization of 3,5-dichloro-2-aminobenzoic acid. Fifty grams (0.24 mole) of 3,5-dichloro-2-aminobenzoic acid is dissolved in a solution of 12 g. (0.3 mole) of sodium hydroxide in 700 ml. of water. To this solution is added 20 g. (0.29 mole) of sodium nitrite, and the solution is cooled to 10° (Note 5). One hundred milliliters of concentrated hydrochloric acid (sp. gr. 1.191) and 200 ml. of water are placed in a 2-1. three-necked flask and cooled to 10°. The cold solution of sodium 3,5-dichloro-2-aminobenzoate and sodium nitrite is then added to the hydrochloric acid solution with cooling (10°) and efficient stirring at such a rate that no appreciable accumulation of undiazotized amine results (Note 6). At the conclusion of the diazotization, the resulting solution is stirred a few minutes with 2 g. of diato-maceous earth and filtered by suction (Note 7). 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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