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Diazirino-sugars

The carbene-generating biotinylated 2-acetamido-2-deoxy-D-glucopyranosyl-amide diazirine derivative 54 and the lactoside 55 have been synthesized for photoaffinity labelling of P-(l - 4)-galactosyl transferase and GMj synthase.  [Pg.150]

The diazirino-mannose derivative 80 has been synthesized from the corresponding mannonolactone oxime (i, MsCl ii, NH3. MeOH iii, I2, EtjO). The use of this and other diazirino-sugars in die synthesis of O- and C-glycosides is covered in Chapter 3. oc-D-Glucopyranosyl-phenyldiazomethane 81 has been synthesized as a mechanism-based a-glucosidase inhibitor. ... [Pg.149]

A review on chemical reagents in photoaffinity labelling has reviewed die role of diazirino- ( azi- ) sugar derivatives. Disodium 3 -azibutyl a-D-mannopyranoside 6-phosphate and tetrasodium 2-azi-l,10-bis-(a-D-mannopyranosyloxy 6-phos-phate)-decane have been synthesis as photoaffinity probes for binding to mannose-6-phosphate receptors. ... [Pg.156]

See other pages where Diazirino-sugars is mentioned: [Pg.150]    [Pg.127]    [Pg.370]    [Pg.156]    [Pg.131]    [Pg.406]    [Pg.150]    [Pg.127]    [Pg.370]    [Pg.156]    [Pg.131]    [Pg.406]    [Pg.107]   


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