Diazepam proprietary names

Diazepam, proprietary name Valium, is frequently used in emergency situations to gain control in status epdepticus. Unfortunately, tolerance to diazepam at the GABA receptor develops rapidly, and diazepam becomes ineffective within 2 to 3 days. Diazepam is therefore not used for long-term control of seizure disorders. 

The generic names diazepam, nitrazepam, flur-azepam are all of benzodiazepines. Their proprietary names are Valium, Mogadon and Dalmane respectively. Names ending in -olol are adrenoceptor blockers in -pril are ACE-inhibitors in -floxacin are quinolone antimicrobials. 

Clonazepam, proprietary name Clonopin, is a benzodiazepine with chemical structure closely related to diazepam. The mechanism of action is the same as described for diazepam, but tolerance does not develop as rapidly as with diazepam. Clonazepam is currently approved for use in absence seizures, infantile spasms, akinetic seizures, and Lennox-Gastaut syndrome. Plasma concentrations associated with maximal effectiveness of the drug range from 15 to 60 ng/mL. At concentrations higher than 80 ng/mL, no additional seizure protection is observed, and toxicity (drowsiness and ataxia) ensues. The most suitable methods adaptable to routine analysis are based on GLC with electron capture detection, although HPLC methods also are effective. ... 

Generic (proprietary) Names diazepam (Valium, Diastat)... 

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