1.5- Diazabicyclo undecane

TABLE 26. Force field (MMl) calculations of l,5-diazabicyclo[3.3.3]undecane 72 and 1,6-diazabicyclo[4.4.4]tetradecan 73 (distances in A, bond angles in degrees, relative energies in kcalmol1)111... 

The reaction of 2//-heptafluorobut-2-ane with l,8-diazabicyclo[5.4.0]-undecan-7-ene 78 (reagent ratio 1 4) leads to tricyclic pyrrole—1,9-diaza-bicyclo[5.4.0]undecano-[a,Z -2]-difluoromethyl-3-trifluoromethylpyrrole 79 (96JFC(79)121). 

Reactions of Aliphatic Nitro Compounds. XXVII. On Formation of a Derivative of l,5-Diazabicyclo(3.3.3 undecane from 1-Nitropropane, Formaldehyde and Ammonia, J. K. N. Jones, R. Kolinski, H. Piotrowska, and T. Urbadski,Rocz. Chem., 31 (1957) 101-109. 

Reaction of 1,4,7-thiadiazonane with bromoacetyl bromide in CHCI3 afforded, instead of expected 4,7-bis-(2-bromoacetyl)-l-thia-4,7-diazacyclononane 115, derivative of l-thionia-4,7-diazabicyclo[5.2.2]undecane 116 as a product of intramolecular cyclization (Scheme 19) <2004AXCol00>. 

Hydrolysis of the 10-chloro derivative 36 in 0.5 M sodium hydroxide solution at 50°C for 6 hr gave the 2,6-diazabicyclo[5.4.0]undecan-l-one (39), probably via the 11-membered azalactam (38) through intramolecular alkylation (84JHC583). 

A convenient and stereoselective, synthetic route was reported for the preparation of 3,7-disubstituted-l,2,5-trithiepanes 209 by the reaction of thiiranes with bis(trimethylsilyl)sulfide (HMDST) followed by intramolecular oxidative cyclization (14HAC678). In the reaction of substituted etha-nolamines with formaldehyde, the desired bis(oxazolidin-3-yl)methanes were prepared as a mixture of products, the ratio of the isomeric 3,8-dioxa-l,6-diazabicyclo[4.4.1]undecane 210 product present was dependent on the substituent on the ethanolamine (14CHE726). Whether the bis(oxazolidin-3-yl)methanes were isolated or the mixtures were taken on for further reaction, the subsequent product was formed exclusively. 

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