Diarylpyrazoles structure

Desiraju, G.R., Gopalakrishnan, B., Jetti, R.K.R., Raveendra, D., Sarma, J.A.R.P. and Subramanya, H.S. (2000) Three-dimensional quantitative structural activity relationship (3D-QSAR) studies of some 1,5-diarylpyrazoles analogue based design of selective cyclooxygenase-2 inhibitors. Molecules, 5, 945-955. 

Cheung KM et al (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg Med Chem Lett 15(14) 3338-3343... 

A number of synthetic compounds, completely unrelated to the structure of natural cannabinoids have been found to act as CB and/or CB2 antagonist/ inverse agonist. The most important member of this class of compounds is rimonabant (29), a diarylpyrazole derivative [57], approved for the treatment of obesity and as an aid in the cessation of cigarette smoking, but later withdrawn from the market because of the severe depression it could induce in sensitive patients. A number of structural motifs significantly different from the p3razole system have been proposed for CB2 selective antagonists, as exemplified by the quinoline derivative 30. 

By definition, cannabinoids comprise a variety of distinct chemical classes which bind to the cannabinoid receptor. These include the classical cannabinoids structurally related to tetrahydrocannabinol, the non-classical cannabinoids, the aminoalkylindoles, the eicosanoids related to the endocannabinoids, 1,5-diarylpyrazoles, quinolines and atylsulphonamides and additional compounds that do not fall into these standard classes. According to their production and origin, there are three types of cannabinoids phytocannabinoids, endogenous cannabinoids, and synthetic cannabinoids. 

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