Diarrhetic shellfish poisoning toxins structures

Figure 5.59 Molecular structures of the diarrhetic shellfish poisons (a) pectenotoxin-6 (PTX6) (b) okadaic acid (OA) (c) dinophysistoxin-1 (DTXl) (d) yessotoxin (YTX). Reprinted from J. Chromatogr., A, 943, Matrix effect and correction by standard addition in quantitative liquid chromatographic-mass spectrometric analysis of diarrhetic shellfish poisoning toxins , Ito, S. and Tsukada, K., 39-46, Copyright (2002), with permission from Elsevier Science.

Murata, M., Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning, Bull. Jpn. Soc.Sci. Fish, 48, 549, 1982. 

The consumption of shellfish (scallops and mussels) harvested during late spring to early summer fiom the northeastern region of Japan quite often results in what is commonly known as diarrhetic shellfish poisoning. An initial chemical investigation of the toxic mussels resulted in the identification (86) of okadaic acid [108], dinophysistoxin 1 (DTXj) [109] and two toxins of unknown structures. In a later study (87), chemical structures of three new polyether toxins, dinophysistoxin- 3 (DTX3)[110], pectenotoxin-1 [111 ] and pectenotoxin-2 [112] were reported. 

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