Diarrhea therapeutic approach

Reseai ch aimed at the identification of novel antiarrythmic agents is targeting Cl channels. Cl channels are involved in cardiac arrythmia, asthma, CF and diarrhea, thus representing targets for therapeutic approaches. 

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cychc adenosine monophosphate (cAMP)-regulated chloride channel whose mutation can generate the hereditary disease cystic fibrosis. CFTR inhibition is a therapeutic potential approach to secretory diarrhea [23-25]. 3-[(3-Tiifluoromethyl)phenyl]-5-[(4-caiboxypheityl)methylene]-2-thioxo-4-thiazolidinone (CFTRjjj -172 Schemes... 

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