Diarrhea darunavir

Darunavir PI2 600 mg bid with ritonavir 100 mg bid Take with food Diarrhea, headache, nausea, rash, hyperlipidemia, t liver enzymes, t serum amylase Avoid in patients with sulfa allergy. See footnote 4 for contraindicated medications... 

Symptomatic adverse effects of darunavir include diarrhea, nausea, headache, and rash. Laboratory abnormalities include dyslipidemia (though possibly less frequent than with other boosted PI regimens) and increases in amylase and hepatic transaminase levels. Liver toxicity, including severe hepatitis, has been reported in some patients taking darunavir the risk of hepatotoxicity may be higher for persons with HBV, HCV, or other chronic liver disease. 

Darunavir is prescribed as a 600 mg/100 mg dosage as DRV/r twice daily for treatment-experienced patients, and 800 mg/100 mg tablets for HIV naive patients.26 Among the array of clinical studies performed, darunavir was well tolerated with the most common side effects being diarrhea and headache.27... 

Comparative studies In an open randomized comparison of darunavir - - ritonavir and lopinavir - - ritonavir in 689 patients the former was associated with fewer possibly treatment-related grade 2-4 gastrointestinal adverse events (7 versus 14%) and specifically treatment-related moderate-to-severe diarrhea (4 versus 10%) adverse events that led to withdrawal occurred in 3% and 7% respectively [173. ... 

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