Diamino-6-mercaptopyrimidine

Three of the 4-6-diamiopyrimidine polymers exhibited CRo values of 20 and greater towards two strains of pancreatic cancer, APSC-1 and PANC-1. [109] There polymers are derived from reaction of dibutyltin dichloride and 4,6-diamino-2-mercaptopyrimidine, 2-chloro-4,6-diaminopyrimidine, and 4,6-diamino-2-hydroxypyrimidine. 

Only the compound derived from the condensation of triphenyl-arsenic dichloride with 4,6-diamino-2-mercaptopyrimidine (poly-(AsDASP)) has been extensively studied (13). It was picked for study because of the presence of the thiol group which is both a potential modifying moiety towards the toxicity of arsenic and a typically desirable metabolite for a number of biological organisms - thus encouraging both select toxicity and metabolism. 

A mixture of 2 g of 4,5-diamino-6-mercaptopyrimidine and 10 ml of 9B% formic acid was heated at 70°C for two hours and then evaporated to dryness on the steam bath to give as a residue, 7-amino-thiazolo (5,4-d) pyrimidine. 

O ethyl 4-amino-2-mercaptopyrimidine 5-catboxylate IS 2-mercaptobenzothiazole 2-mercaptopyrimidine B 4,6-diamino-2-mercapto-1,3,5-triazine... 

Arsenic-containing antibacterial polymers have been prepared by the reaction of triphenylarsenic dichloride with 2,4-diamino-6-mercaptopyrimidine. 

---