Di indolyl

Butane, 2,3-0-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)-catalyst in homogeneous asymmetric hydrogenation, 6, 781 Butane-1,4-dioic acid, 2,2-di(indolyl)-synthesis, 4, 226 Butanenitrile, 4-hydroxy-dihydropyran synthesis from, 3, 769 Butanoic acid, -y-aryl-y-amino-synthesis, 1, 433 1-Butanol... 

When the di-indolyltetrahydroquinoxaline derivative (25) is heated with an ethanolic solution of potassium hydroxide (10%) in diethyleneglycol, it is converted into a 2,3-di-indolyl-4-methylbenzodiazepine (85KGS132, 85KGS1551) (Scheme 20). 

Rad-Moghadam K, Sharifi-Kiasaraie M, Taheri-Amlashi H (2010) Synthesis of symmetrical and unsymmetrical 3,3-di(indolyl)indolin-2-ones under controlled catalysis of ionic liquids. Tetrahedron 66 2316-2321... 

Sarrafi, Y, Alimohammadi, K., Sadatshahabi, M. and Norozipoor, N. 2012. An improved catalytic method for the synthesis of 3,3-di(indolyl)oxindoles using Amberlyst 15 as a heterogeneous and reusable catalyst in water. Afonafs/j. Chem. 143(11) 1519-1522. 

Sanna reported that l,3-di(3-indolyl)-l,3-dioxo-%-propanc (266) and l,4-di(3-indolyl)-l,4-dioxo-M-butane (267) were formed by the action of malonyl chloride and succinyl chloride, respectively, on the indole Grignard reagent in ether, and analogous products could be obtained from 2-methylindole. 

In 1956 Ames et al. reported that a low yield of l-benzamido-2,2-di-(3-indolyl)ethane (316) was obtained in an attempt to prepare 3-(2-benzamido-l-hydroxyethyl)indole (317) by the action of hcnzamido-acetaldehyde on indole magnesium iodide in ether. 

Majiina and Kotake prepared 2,2-di(3-indolyl)propane (336) by the action of acetone on indole magnesium iodide in other or anisole. Recently 1 -indolyl derivatives have been o btained as primary products by interaction of ketones with indole Grignard reagents for example acetone gave a 75% yield of 2-(l-indolyl)propan-2-ol (337). 

Oddo and Mingoia reported that di(3-indolyl) ketone (380), di(2-indolyl) ketone (381), and di(l -indolj l) ketone (382) were obtained by... 

Aminophthalate anion Atmospheric pressure active nitrogen Analyte pulse perturbation-chemiluminescence spectroscopy Arthromyces rasomus peroxidase Ascorbic acid Adenosine triphosphate Avalanche photodiode 5-Bromo-4-chloro-3-indolyl 2,6-Di-t< r/-bu(yl-4-mclhyl phenol Bioluminescence Polyoxyethylene (23) dodecanol Bovine serum albumin Critical micelle concentration Calf alkaline phosphatase Continuous-addition-of-reagent Continuous-addition-of-reagent chemiluminescence spectroscopy Catecholamines Catechol... 

Fig. 12 Reaction of indole with isatin to form 3,3-di(3-indolyl)oxindole...

The probable pathway of the reaction is shown in Fig. 14 and it seems to be an addition of the indole to the carbonyl group of isatin, followed by the condensation of a second indole moiety on the same carbon, resulting in the formation of 3,3-di (3-indolyl)oxindole. 

Treatment of 4-methoxy-2-oxazolidinone 86 with indolylmagnesium bromide 87, followed by A-protection with a ferf-butoxycarbonyl (Boc) group affords NJd -di-Boc-4-(3-indolyl)-2-oxazolidinone 88. Subsequent treatment with A-bromosuc-cinimide (NBS) in the presence of azobisisobutyronitrile (AIBN) followed by electrochemical reduction yields the protected 4-(3-indolyl)-2(3//)-oxazolone 90 (Fig. 5.23). The Boc groups are easily removed by pyrolysis."" "" ... 

Zwei Aquivalente 4-Nitro-phenyldiazonium-tetrafluoroborat reagieren in waBrigem Medium mit Di-3-indolyl-methan bzw. Bis-[l-methyl-3-indolyl]-methan unter Bildung von 3-(4-Nitro-phenylazo)- bzw. l-Methyl-3-(4-nitro-phenylazo)-indol in hohen Ausbeuten (> 90% Weg ). 

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