Di-amination

Lloyd-Jones, Booker-Milburn and coworkers described a novel Pdn-catalyzed di-amination of 1,3-butadienes as 6/1-384 with ureas 6/1-383 to give 6/1-385 (Scheme 6/1.97) [181]. The best results were obtained in the presence of p-benzoquinone, whereas with Cu-salts the turnover was inhibited. 

One of the major constituents of urine is the di-amine, urea (III). Each amine group in urea should remind us of ammonia in Equation (6.11). Solutions of urea in water are basic because the two amine moieties each abstract a proton from water, to generate an ammonium salt and a hydroxide ion ... 

Notes. (1)Tpypor = tetrapyridlporphyrin pipz = piperazine H5hpdta = 2-hydroxypropane-1,3-di-amine-A/,A/,A/, /V"-tetraaceticacid organic polyammonium cation = tris[2-(trimethylammonium)ethyl]-1,3,5-benzenetricar-boxylate 1,3,5-tris[4-(A/,A/,A/-trimethylammoniumethylcarboxyl)phenyl]benzene DODA = dimethyl dioctade-cylammonium. 

If we replace the di-alcohol in the preceding reaction with a di-amine we get ... 

The perinone ring system is thus formed by condensation with aromatic o-di-amines. Reaction of o-phenylenediamine with the monoanhydride is typically achieved in glacial acetic acid at 120°C. A mixture of the cis and trans isomers evolves, which appear as mixed crystals ... 

Phenylquinoxalines - Polyphenylquinoxalines (PPQ) prepared from the reaction of aromatic bi s (o-di amines) and aromatic bis (phenyl-ot-diketones) are high temperature thermoplastics. They are process-able with little or no volatile evolution at relatively high temperatures (> 316°C) and pressure (-1.38 MPa) by virtue of their thermoplasticity. Like other thermoplastics, the processability is governed primarily by the chemical structure, molecular weight and molecular weight distribution. 

Ishikawa and co-workers also reported a class of structurally modified guanidines for promotion of the asymmetric Michael reaction of ierf-butyl-diphenylimino-acetate to ethyl acrylate [124,125]. In addition to a polymer support design (Scheme 69), an optical resolution was developed to achieve chiral 1,2-substituted ethylene-l,2-di-amines, a new chiral framework for guanidine catalysis. The authors discovered that incorporating steric bulk and aryl substituents in the catalyst did improve stereoselec-tivitity, although the reactivity did suffer (Scheme 70, Table 4). 

J. IODO(METHYL) (A,N,N, A -TETR AMETH YLETH YLENE-DI AMINE) PALLADIUM(II)... 

AMNES-CYCLOALIPHATIC AMINES] (Vol 2) tran s-1,4-Di (amin omethybcycl oh exan e [10029-07-9]... 

AMINES - AMINES,AROMATIC - DI AMIN OTOLUENES] (Vol2) 2,4-Diammo-6-(3,3,3-tribromopropyl)-l,3,5-triazme [62160-38-7]... 

AMINES - AMINES,AROMATIC - DI AMIN OTOLUENES] (Vol2)... 

A number of isohexide mono- and di-amines (164) failed to exhibit antitumor activity. A few of them are weak antiflammatories, albeit rather... 

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