Dextromethorphan drug class

A -methyl-D-aspartate antagonists Dextromethorphan Limited number of drugs in this class are available for human use. Study findings have been negative. 

Patients should not use dextromethorphan if they are taking any drug in the class known as monoamine oxidase inhibitors (MAOI), including phenelzine (Nardil), isocarboxazid (Marplan), and tranylcypromine (Parnate), which are used in the treatment of depression. The combination of MAOIs with dextromethorphan can lead to toxic levels of dextromethorphan in the blood. 

Dextromethorphan is known to interact with quini-dine and terbinafine. In both cases, there is a reduction in the metabolism of dextromethorphan by the liver. Terbinafine is a drug used to treat fungal infections. Quinidine is used for the treatment of malarial infections and heart rhythm problems. There has been a case report of a drug interaction between the use of fluoxetine (Prozac) and dextromethorphan. Fluoxetine is an antidepressant in the class of drugs called serotonin reuptake inhibitors. 

The World Health Organization classified dextromethorphan as a non-analgesic, non-addictive substance in the late 1960s. In 1970, the Controlled Substance Act further added weight to this notion that dextromethorphan is not in the same class of drugs as its opiate forbearers in its abuse potential. This led to the decision of the DEA to leave dextromethorphan off its schedules of controlled substances. 

While it is true that dextromethorphan is not technically a member of the opiate family, it is distantly related in its chemical composition. Dextromethorphan is created by from levomethorphan, which is classified as an opioid, the synthetic or semi-synthetic relatives of the natural chemical family called the opiates. Levomethorphan has most of the same qualities of all drugs in the opiate and opioid classes. This includes strong suppressive effects on the respiratory system. It is these strong effects on the respiratory system that make dextromethorphan an effective anti-cough agent. Opiate and opioid compounds have anti-cough properties but produce greater overall respiratory depression than dextromethorphan. 

Synonyms DM Dextromethorphan hydrobromide Demorphan 3-Methoxy- -methylmorphinan d-Methorphan Drug store wine Robowing Chemical/Pharmaceutical/Other Class The methyl ether of the dextrorotatory form of levor-phanol, an opiate analgesic Chemical Formula C18H25NO Chemical Structure ... 

The multiple surface plasmon resonance (SPR) sensor was appUed for detection and quantification of dextromethorphan (36) with the use of molecularly imprinted P-CD polymer [81]. The cough suppressant 36 is a marker drug used to identify the activity of the CYP2D6 class of p450 monooxygenases. It was found that the sensor may be used to measure the consumption of 36 by CYP enzymes. 

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