Developmental stages development

Improve characterization of the differences in toxicokinetic and toxicodynamic properties of xenobiotics at different developmental stages. Develop databases of developmental stage-specific physiological and pharmacokinetic parameters in both human and animal studies. 

B) at the indicated stages, and the PGl, PG2, and total PG activities were determined by differential heat inactivation. Each time point is the average of at least two separate extractions assayed in duplicate. The developmental stages are MG, mature green Br, breaker stage, (time of first external color development) and +2, +5, +7, and +10 are days after breaker. 

The factors necessary to achieve quality in a product during the developmental stage have been discussed. The formulator of a new product must consider the manufacturing process to be used for full-scale production of the product. Many new product failures or deficiencies occur because of inability to resolve or foresee production-related problems, rather than to poor product development per se. Therefore, the... 

Children sometimes differ from adults in their susceptibility to hazardous chemicals, but whether there is a difference depends on the chemical (Guzelian et al. 1992 NRC 1993). Children may be more or less susceptible than adults to health effects and the relationship may change with developmental age (Guzelian et al. 1992 NRC 1993). Vulnerability often depends on developmental stage. There are critical periods of structural and functional development during both pre-natal and post-natal life and a particular structure or function will be most sensitive to disruption during its critical period(s). Damage... 

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