Deuteriobromic acid

Bromine (7 ml) is added dropwise to a mixture of white sand (14 g) and red phosphorus (3 g, dried at 165° under vacuum) moistened with 5 ml of deuterium oxide. The apparatus is fitted with an exit tube to allow the liberated deuteriobromic acid to pass through two U-tubes and into a receiving flask. The first trap contains glass beads and is cooled in an ice-salt slurry. The second contains glass beads and red phosphorus moistened with deuterium oxide. The deuterium bromide gas is collected in the appropriate solvent at ice bath temperature. A small amount of phosphorus pentoxide should be added to remove any deuterium oxide if anhydrous reagent is required. 

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A reaction which is of considerable importance for the selective labeling of a position adjacent to a carbonyl group is the treatment of a-halo ketones (mainly bromides) with zinc in acetic acid-OD, or deuteriobromic acid at... 

Deuterioammonia, 188, 190 Deuteriobor ation, 191 Deuteriobromic acid, 214 Deuteriodiborane, 191 Deuterio-Raney nickel, 215 Deuterium gas and a surface catalyst, 199 Deuterium and tritium gas, 179 3,17/8-Diacetoxyestra-3,5-diene, 486 3,20-Diacetoxypregna-3,5,20-triene, 411 (20S)-2/3,3j3-Diacetoxy-5a-pregn-7-en-6 one-20-carboxylic acid methylester, 301 Diborane, 89, 100... 

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