Detrusor muscle contractility

Bladder underactivity may also result in overflow incontinence. Under certain circumstances, the detrusor muscle of the bladder may become progressively weakened and eventually lose the ability to voluntarily contract. In the absence of adequate contractility, the bladder is unable to empty completely, and large volumes of residual urine... 

For prognostic and therapeutic reasons, only functional classifications based on the reflex activity of the different muscle groups involved in storing and evacuating urine should be used. One commonly used classification is based primarily on the reflex activity of the detrusor muscle, defining three types contractile detrusor (detrusor hyperreflexia), acontractile detrusor (detrusor areflexia), and intermediate detrusor (mixed type). 

Based on the reflex activity of the detrusor muscle and the fact that most children with myelodysplasia do not fit into the classical anatomical and neurological categories, a classification system with three types of bladder dysfunction (contractile, acontrac-tile, and intermediate) is in use (Rickwood et al. 1982). 

A novel series of 1-aryl-3-(thiophen-2-yl)-1 H-1,2,4-triazol-5(4H)-one derivatives was synthesized and evaluated as detrusor muscle relaxants for the treatment of urinary incontinence. The effects of these compounds on bladder contractile function were determined in vitro by using isolated rat bladder strips from male Sprague-Dawley rats that were pre-contracted with carbachol. The results of the SAR studies in this series led to the identification of several potent smooth muscle relaxants. The design, synthesis, and SAR of the series will be presented. 

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Malmqvist U, Arner A, Uvelius B (1991b) Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction—a comparative study in rat and man. Scand J Urol Nephrol 25 261-267... 

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