Detection of Endometrial Stromal Tumors

Note that this translocation is not distinctive for the high-grade poorly differentiated endometrial stromal sarcoma. In a case report the t(10 17)(q22 pl3) translocation was described in association with the high-grade variant, which may signify that this variant has a different pathogenesis or histogenesis. 

As the endometrial stromal tumors does not have a specific immunophenotype and the expression of CD 10 and steroid hormones can also be noted in some other tumors such as hepatocellular carcinoma and few types of renal cell carcinoma, the detection of the JAZFl-JJAZl fusion transcript can be used as a further diagnostic feature to distinguish the endometrial stromal tumors from other tumors, specially if the examined tissue represents a metastatic tumor of unknown primary. 

Method The method used is mRNA extraction from frozen or paraffin-embedded 

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