Desorption of drugs

The separation must be as rapid as possible to prevent desorption of drug from the particle [170],... 

Finally, research trends on this topic include the study of competitive adsorption, for instance, between NOM and micro-pollutants such as pesticides adsorption of bacteria which in turn can catalyze the decomposition of the adsorptive adsorption/desorption of drugs for medical applications and modifications of the adsorptive depending on the solution and carbon surface chemistry. 

In a series of papers, Gupta et al. (109-112) studied the in vitro release properties of heat-stabilized BSA microspheres containing adriamycin. The biphasic release of drug was attributed to its location in the microsphere. The initial release results from surface desorption and diffusion through pores, while the later release arises from drug within the microsphere, which becomes available as the microsphere hydrates. 

Reyzer, M. L. Hsieh, Y Ng, K. Korfmacher, W. A. Caprioli, R. M. Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry. J. Mass Spectrom. 2003, 38, 1081-1092. 

Ion mobility spectrometry (IMS [43]). Solid phase microextraction (SPME) using a 100 pm polydimethylsiloxane (PDMS) SPME fibre was used for head-space sampling and preconcentration of volatile markers of cocaine, MDMA and marijuana (methyl benzoate, piperonal and terpenes, respectively) in cargo containers. Analysis was then performed by IMS after thermal desorption of the drug markers from the fibre into the IMS analyser. 

Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules... 

Huikko, K., Oestman, P., Sauber, C., Mandel, F., Grigoras, K., Franssila, S., Kotiaho, T., and Kostiainen, R. (2003). Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs. Rapid Commun. Mass Spectrom. 17 1339-1343. 

Kertesz V, van Berkel G, Vavrek M, Koeplinger K, Schneider B, Covey T (2008) Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography. Anal Chem 80 5168-5177. doi 10.1021/ac800546a... 

Drexler D, Garrett T, Cantone J, Diters R, Mitroka J, Conaway M, Adams S, Yost R, Sanders M (2007) Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissue. J Pharmacol Toxicol Methods 55 279-288. doi 10.1016/j. vascn.2006.11.004... 

The aim of this work is to investigate the adsorption and desorption of a pharmaceutical compound, taken as representative of a complex chemical molecule, on activated carbon. Nimesulide is a non steroidal anti-inflammatory drug currently used in defeating respiratory tract infections. 

The use of supramolecular interactions to bind a pharmaceutically active drug noncovalently to a polymer in order to achieve slow release was presented by Puskas et al. [96]. Here, a side-chain functionahzed poly(styrene) bearing thymine moieties (Fig. 20) was prepared and complexed with phenol as a complexing agent. The release of the bound phenol was studied in aqueous buffer solution, revealing a slow desorption within 4.5 hours from the polymer. Thus, this system is adaptable for slow release of drugs from polymeric matrices. 

Singh M, Lumpkin JA, and Rosenblatt J. Mathematical modeling of drug release from hydrogel matrices via a diffusion coupled with desorption mechanism. J. Control. Rel. 1994 32 17-25. 

Endothermic Fusion Vaporization Sublimation Desorption Desolvation Melting of drug substances purity evaluations Evaporation of liquid or semisolid excipients Removal of frozen water during lyophilization Drying of wet granulated formulations Removal of stoichiometric water from crystalline hydrates... 

---