Desmoplastic medulloblastoma

Desmoplastic medulloblastoma Regions of medulloblastoma and fibrosis Synaptophysin S-1 00 type IV collagen neurofilament (R) GFAP (R) Lateral cerebellum CNS meninges (extra-axial) ... 

FIGURE 20.39 This desmoplastic medulloblastoma shows pale islands on H E (A) that contain synaptophysin-positive cells (B). Adjacent sections of the same region of tumor show that densely crowded cells form reticulin-positive bands (C) around the pale islands and that these bands contain most of the MIBl -positive cells (D). 

Katsetos CD, Herman MM, Frankfurter A, et al. Cerebellar desmoplastic medulloblastomas A further immunohistochemical characterization of the reticulin-free pale islands. Arch Pathol Lab Med. 1989 113 1019-1029. 

Neuroblastomas are small, round, blue cell tumors that may arise in the adrenal gland and a variety of extra-adrenal sites. The differential diagnosis is wide and includes rhabdomyosarcoma, Ewing s sarcoma-primitive neuroectodermal tumor (ES-PNET), medulloblastoma, small cell osteosarcoma, lymphoblastic lymphoma, blastematous Wilms tumor, and small cell desmoplastic tumor. Numerous markers have been used for the diagnosis of neuroblastomas including NE markers, cytoskeletal proteins, catecholamine-synthesizing enzymes, and neuroblastoma-"specific antibodies (Eig. 

---