Designer drugs chemical properties

Leeson, P. D., Davis, A. D., Steele, J. Drug-like properties guiding principles for design - or chemical prejudice ... 

Valvani, S.C., Yalkowsky, S.H. (1980) Solubility and partitioning in drug design. In Physical Chemical Properties of Drug. Med. Res. Series, volume 10., pp. 201-229, Yalkowsky, S.H., Sinkula, A.A., Valvani, S.C., Editors, Marcel Dekker, New York. 

The dosage-form design is guided by the properties of the drug candidate. If an NCE does not have suitable physical and chemical properties or pharmacokinetic attributes, the development of a dosage form (product) may be difficult and may sometimes be even impossible. Any heroic measures to resolve issues related to physicochemical and biopharmaceutical properties of drug candidates add to the time and cost of drug... 

Designating property-based guidelines for designing chemicals such that they are minimally absorbed and, therefore, should be less toxic, is analogous to a known phenomenon in medicinal chemistry - designing drug compounds such that they are likely to be well absorbed into the body to optimize the desired pharmacological effect. 

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