Moderation, design strategies

Hazard and Risk Analysis Consideration should be given to identifying process hazards as early as possible in the process equipment design, so that measures can be taken to reduce or eliminate the hazards. Inherently safer design strategies, such as minimize, substitute, moderate, and simplify, should be implemented. 

Cdk4 inhibitor 7, which was obtained from the new de novo design strategy, is moderately selective for Cdk4 over 14 representative kinases except for the Cdk family however, compound 7 inhibits Cdkl and Cdk2 in addition to Cdk4 with almost same potency [20]. 

Molecular control over EHS as well as performance properties were attained through a design strategy that started with the creation of a chemical library composed of 239 potential solvent candidates. Relevant platform molecnles were selected in order to fulfil a diversity of design criteria inclnding a high renewable atom index, moderate to low vapour pressure and a cost-effective synthetic accessibility (see Table 10.4). 

The integration office may also assume an arbitration function and moderate discussions in difficult situations, for example when an optimum organizational design is being derived for individual units. Additional tasks may include developing the communication strategy or clarifying personnel matters. 

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