Design strategies human factors

In models of MND, therapeutic manipulations, manipulation of expression of selected genes in specific cell populations [15, 16], creation of chimeric animals to test whether abnormalities are cell autonomous [17], administration of trophic factors to prevent trophic cell death [18-20] and testing of a variety of drug therapies [21-24] have been used to try to ameliorate phenotypes and thus provide insights into disease mechanisms and potential treatment strategies [1, 3, 4, 15, 25, 26]. Results of these studies are being used to design novel therapies to be tested in clinical trials in humans. 

INTRODUCTION 14 PESTICIDE CATEGORIES 15 PESTICIDE HANDLERS 15 Agricultural Pesticide Handlers 15 Tasks Performed by an Individual 16 Factors Affecting Exposure 16 Residential and Institutional Pesticide Handlers 18 Families of Pesticide Handlers 19 STUDY DESIGN CONSIDERATIONS 20 Worker Stratification 21 Routes of Exposure 21 Respiratory Exposure 21 Dermal Exposure 21 Sampling Strategy Selection 21 Statistical Analysis 22 PROTECTION OF HUMAN SUBJECTS 22 PESTICIDE EXPOSURE MONITORING METHODS 23 Passive Dosimetry 23... 

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