Design protein surface receptors

A. J. Wilson, J. Hong, and A. D. Hamilton, Pattern-based detection of different proteins using an array of fluorescent protein surface receptors, J. Am. Chem. Soc. 126, 5656-5657 (2004). (f) C. Schmuck, and L. Geiger, Dipeptide binding in water by a de novo designed guanidinio-carbonylpyrrole receptor, J. Am. Chem. Soc. 126, 8898-8899 (2004). 

VEGF-Trap is a protein-based product candidate designed to bind all forms of VEGF and the related P1GF, and prevents their interaction with cell surface receptors. VEGF Trap is being pursued in phase II... 

Many of the drugs used in the treatment of hypertension and cardiovascular disease are designed to interfere with the action of cell-surface receptors that couple to heterotrimeric G proteins. 

The most popular OTC sleep aids are those that contain antihistamines such as diphenhydramine or doxylamine (Table 3.1). As noted in Chapter 1, nerve cells in the brain communicate with each other by secreting chemicals called neurotransmitters. One such neurotransmitter that regulates sleep is histamine. When histamine is released by a nerve cell, it diffuses over to the target nerve cell and binds to specialized proteins called receptors located on the outer surface of the nerve cell. These receptors are specially designed to bind only histamine, and when they do, the target nerve cell will become either activated or deactivated. In the brain, histamine serves the function of keeping us awake, and when drugs such as antihistamines are taken, they block the ability of histamine receptors to bind histamine. 

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