Design organic synthesis, powers

The formation of carbon-carbon bonds using olefin metathesis methodology is a powerful technique in fine organic synthesis and polymer chemistry. The increasing importance of these reactions is reflected by the numerous publications over the last few years. Many of these pubhcations deal with the design and apphca-tion of polymer-supported olefin metathesis catalysts with the aim to overcome the common drawbacks of the homogeneous catalysts low thermal stability and difficulties associated with their recovery from the reaction mixtures. The modem state of art in this important field is described in chapter 11 of this volume. 

Recently, the power of designer acid catalysts has generally increased as a result of the development of the catalytic enantioselective versions described here. In particular, combined acid catalysis is still very much in a state of infancy, and there is still much more to learn with regard to new reactivity. The ultimate goal is a more reactive, more selective, and more versatile catalyst. We beheve that the realization of such an objective would be a tremendous benefit for the further development of organic synthesis, including green chemistry. 

One may expect that by taking advantage of suitably designed supramolecular features it will be possible to generate a variety of highly complex architectures that would not be accessible otherwise (or only with low efficiency). Such supramolecular assistance adds a new direction with powerful means to organic synthesis. 

Kayser MM (2009) Designer reagents recombinant microorganisms new and powerful tools for organic synthesis. Tetrahedron 65 947-974... 

Antibodies combine some of the best features of synthetic and enzymatic catalysts. By fusing programmable design with the powerful selective forces of biology, this new technology has the potential to provide many valuable tools for stereoselective organic synthesis in the next century. 

Despite the uncertain beginning, a variety of optically active tertiary arsines is now available for application in inorganic and organic synthesis. Tertiary arsines are powerful ligands for metals in a range of oxidation states, a feature that makes them particularly suitable for the design of complexes for stereochemical investigations and for use in... 

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