Design of Non-natural Amino Acid

Introduction of amino and carboxyl groups to metal compounds has been tried and some compounds have been reported. For stability (against oxidation, heat, moisture, acid, base, etc.) and synthetic facility, the selection of the ligand is confined to chelates with N or O donor sets and sufficiently stable organometals like ferrocene. Among monodentate ligands, pyridine is very useful for chemical modifi- 

The most favorable compound for non-natural amino acid requires the following 1) stability to air, moisture, acid, base and heat, 2) complex inert to ligand exchange reaction, 3) electrochemical stability and 4) synthetic facility. Consequently, we selected ruthenium-polypyridine compounds and ferrocene derivatives shown in Fig. 3.33(b). Palladium compounds were prepared for spectroscopic comparisons and investigation. 

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