Design for eQTL Studies

A more recent application of microarray is in the quantitative trait locus (QTL) mapping area. The conventional analysis of QTL is on phenotypic traits such as blood pressure and body weight, which are measured from each individual in a genetic segregating family of individuals resulting from crosses or pedigrees. In recent 

Allison, D. B., et al. (2002). A mixture model approach for the analysis of micioarray gene expression data. 

Altman, N. S., and Hua, J. (2006). Extending the loop design for two-channel microarray experiments. 

Bar-Joseph, Z. (2004). Analyzing time series gene expression data. Bioinformatics, 20 2493-2503. Bueno Filho, J. S., Gihnour, S. G., and Rosa, G. J. (2006). Design of microarray experiments for genetical genomics studies. Genetics, 174 945—957. 

Churchill, G. A. (2002). Fundamentals of experimental design for cDNA microarrays. Nat. Genet., 32(Suppl. 2) 490-495. 

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