Design and Discovery

Kuntz I D 1992. Structure-Based Strategies for Drug Design and Discovery. Science 257 1078-1082. 

Chemical self preservation, p. 74 Drugs by design and discovery, p. 96 Drug delivery, p. 344 Physiological buffers, p. 453... 

Kuntz ID. Structure-based strategies for drug design and discovery. Science 1992 257 1078-82. 

The size restrichons of this chapter does not allow us to treat all methods and applicahons which are important in drug design and discovery in more detail. Although the basics for their understanding are described, screening technologies. 

Copeland, R. A., and Anderson, P. S. (2001) in Textbook of Drug Design and Discovery, 3rd ed., P. Krogsgaard-Larsen, T. Liljefors, and U. Madsen, eds., Taylor and Francis, New York, pp. 328—363. Cornish-Bowden, A. (1995), Fundamentals of Enzyme Kinetics, Portland Press, London. 

Physiologically based pharmacokinetic models provide a format to analyze relationships between model parameters and physicochemical properties for a series of drug analogues. Quantitative structure-pharmacokinetic relationships based on PB-PK model parameters have been pursued [12,13] and may ultimately prove useful in the drug development process. In this venue, such relationships, through predictions of tissue distribution, could expedite drug design and discovery. 

M. Prato, K. Kostarelos, and A. Bianco, Functionalized carbon nanotubes in drug design and discovery, Acc. Chem. Res., 41 (2008) 60-68. 

Krogsgaard-Larsen, P. Liljefors, T. Madsen, U. (Eds.) Textbook of Drug Design and Discovery -, Taylor Francis London, 2002. 

Krogsgaard, L. 2002. Textbook of Drug Design and Discovery. Taylor and Francis. 

Dean, P.M., et al., "Industrial-Scale, Genomics-Based Drug Design and Discovery," Trends Biotechnol., 19, 288-292 (2001). 

T Tokumura. A screening system of solubility for drug design and discovery. Pharm. Tech. Japan 16 1839-1847 (2000). 

Progress in the years following World War n has been exponential and greatly affected by two fundamentally important developments. These have been, firstly, the progress made by medicinal chemists and pharmacologists in rational drug design and discovery and, secondly, the discovery and development of the computer. 

---