Derwent Selection database

ITPAIS, the Image Technology Patent Information System was developed between 1975—1985 by Eastman Kodak Co., Agfa-Gevaert (Antwerp/Leverkusen), and Fuji Photo Film Co., Ltd., and encompasses selected patents and Hterature references related principally to the chemical aspects of image technology. Search terms used for this table were the same as in the previous edition, and the Derwent patent database was used for the search data presented here. 

Barreca et al screened for non-nucleoside reverse transcriptase inhibitors of HIV-1 by searching the Derwent World Drug Index (WDI) and the Chemicals Available for Purchase (CAP) databases with a Catalyst model generated by LigandScout. A Fit value cutoff of 3.0 and Lipinski filters, followed by docking, led to the selection of three compounds, two of which were commercially available. A search for available close analogues of all three compounds finally led to the purchase of six compounds, of which five were shown to be active. 

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