Derwent world drug index

WDl Derwent World Drug Index provided by Thomson Scientific, http // scientific.thomson. com / products /dwpi. 

WDI, the Derwent World Drug Index, is available from Daylight Chemical Information Systems, 2004, http //www.daylight.com/... 

Most prediction tools for druglikeness use the MDL Available Chemicals Directory (ACD) [89] as a list of nondrugs and one of three databases as a list of drugs MDL Drug Data Report (MDDR) [89], MDL Comprehensive Medicinal Chemistry (CMC) [89], or Derwent World Drug Index (WDI) [90]. 

Derwent World Drug Index, Derwent Information, London, Nov. 1998. 

Thompson Derwent. Thompson Derwent World Drug Index scientific.thomson.-com/products/wdi. 

In 2001, Lee and Schneider17 compared the properties of trade drugs (taken from the Derwent World Drug Index, WDI, n=5151) and natural products (taken from the BioScreenNP database, n= 10 495). These investigators described the comparison of parameters applicable only to the rule of five (molecular weight, log P, number of H donors per molecule, number of N per molecule, number of O per molecule and percentage of rule of five alerts). 

Derwent World Drug Index, MDL ISIS/ HOST software, Derwent Information Ltd. http //thomsonderwent.com/chem (2003). 

Barreca et al screened for non-nucleoside reverse transcriptase inhibitors of HIV-1 by searching the Derwent World Drug Index (WDI) and the Chemicals Available for Purchase (CAP) databases with a Catalyst model generated by LigandScout. A Fit value cutoff of 3.0 and Lipinski filters, followed by docking, led to the selection of three compounds, two of which were commercially available. A search for available close analogues of all three compounds finally led to the purchase of six compounds, of which five were shown to be active. 

WDI (Derwent World Drug Index) Version 2001/01 (issue 18), Derwent information Ltd. 2001 http //umw.derw erat.com. 

Derwent World Drug Index, Version 96.2, Derwent Ltd, London, 1996 in Catalyst data format, available from Accelrys Inc, 9685 Scranton Road, San Diego, CA 92121-3752, USA. 

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