Dermatan sulfate hexosamine

A glycosaminoglycan is a heteropolysaccharide consisting of repeating disaccharide sequences, where each disaccharide contains a hexosamine and a hexuronic acid chondroitin sulfate, dermatan sulfate, heparin, and heparan sulfate). However, in keratan sulfate, the hexuronic acid moiety is replaced by a hexose [8, 28]. These... 

Reduction of methylated desulfated dermatan sulfate with sodium boro-hydride transformed the L-iduronic acid moiety into an L-idose moiety. Hydrolysis, followed by adsorption of the hexosamine fraction, gave a neutral fraction consisting of sirupy i,6-anhydro-2,3-di-0-methyl-/ -L-ido-pyranose (XXIX), identical with a synthetic sample, and of a mixture of 2,3-di-O-methyl, 2-0-methyl and 3-O-methyl-D-glucose. The yield of XXIX was low, because of the volatility of the substance, which was further characterized as a crystalline mono- -azobenzoate. No other methylidoses were observed . 

These materials are also called aminopolysaccharides by Kent (K15, K16) or mucopolyuronides by Blix (B22). They contain uronic (hexu-ronic) acid, usually n-glucuronic acid. Only one other uronic acid occurring together with n-glucuronic acid, namely t-iduronic acid, has been found in chondroitin sulfate B (dermatan). In addition to uronic acid, most of these materials, with the exception of hyaluronic acid, contain sulfates (in ester form). They also contain hexosamine as glucosamine or galactosamine, frequently in acetylated form. 

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