Dermal absorption/toxicity species differences

Oral administration exhibited moderate to high toxicity in different species showing LDso within the range 150-750 mg/kg also moderately toxic by dermal absorption such increased toxicity of this compound over other triazines may be attributed to the presence of nitrile functional group in the molecule teratogenic effects in experimental animals persists in the environment. 

No studies were located that specifically examined species-related differences in selenium pharmacokinetics. Similar patterns of absorption, distribution, and elimination have been reported for human and animal systems and the dermal, endocrine, and neurological effects of chronic exposure in humans are similar to those reported for animals exposed to very high doses of selenium. However, species-specific differences in toxicity are present (e.g., the main effect of selenium toxicity in rodents is damage to the liver, which is not observed in humans) and this may represent evidence of underlying differences in how selenium is metabolized. 

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