Derivatives of 1,1-Ferrocene Dicarboxylic Acid

Hirao and coworkers were the first to report and investigate compotmds of the general composition Fe(C5H4-CO-Ala-Pro-OR)2, with (R= Me, Et, n-Pr, Bn) [18,19). 

Metal M Substituent 1 Substituent 2 Chirality of amino acids Chirality at metallocene Ref. 

Pepstatin is a potent naturally occurring inhibitor of aspartic proteases, including HIV-1 protease and pepsin [29-31]. It will be interesting to investigate the physiological applications of these ferrocene peptide conjugates (see also Section 5.3). 

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