Depression modafinil

Substance-Induced Anxiety Disorder. Numerous medicines and drugs of abuse can produce panic attacks. Panic attacks can be triggered by central nervous system stimulants such as cocaine, methamphetamine, caffeine, over-the-counter herbal stimulants such as ephedra, or any of the medications commonly used to treat narcolepsy and ADHD, including psychostimulants and modafinil. Thyroid supplementation with thyroxine (Synthroid) or triiodothyronine (Cytomel) can rarely produce panic attacks. Abrupt withdrawal from central nervous system depressants such as alcohol, barbiturates, and benzodiazepines can cause panic attacks as well. This can be especially problematic with short-acting benzodiazepines such as alprazolam (Xanax), which is an effective treatment for panic disorder but which has been associated with between dose withdrawal symptoms. 

Fava M, Judge R, Hoog SL, et al Fluoxetine versus sertraline and paroxetine in major depressive disorder changes in weight with long-term treatment. J Clin Psychiatry 61 863-867, 2000 Fava M, Thase ME, DeBattista C A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness. J Clin Psychiatry 66 85-93, 2005... 

Amphetamines and related psychostimulants, modafinil and caffeine (ingested as capsules or as caffeinated drinks), produce feelings of increased energy and activity. These effects are particularly pronounced if subjects are engaged in strenuous or monotonous activities of longer duration. According to some reports, there seems to be a minority of subjects who show negative responses to stimulants and may feel tired, listless and occasionally even depressed (Corr and Kumari, 2000). 

Mirtazapine, modafinil, atomoxetine (add A/ith caution and at lower doses since bupropion could theoretically raise atomoxetine levels) both for residual symptoms of depression and attention deficit disorder... 

Modafinil is itself an augmenting therapy to antidepressants tor residual sleepiness and fatigue in major depressive disorder... 

Controlled studies suggest modafinil Improves attention In OSAHS, shift work sleep disorder, and ADHD (both children and adults), but controlled studies of attention have not been performed In major depressive disorder... 

Maser RV, Liao B, Pandya R. Modafinil-induced orofacial dyskinesias in an elderly patient with refractory bipolar depression. J Neuropsychiatry Clin Neurosci 2010 22 4. 

Luborzewski A, Regen F, Schindler F, Anghelescu 1. Modafinil-induced reversible hyperkinetic nondystonic movement disorder in a patient with major depressive disorder. J Neuropsychiatry Clin Neurosci 2006 18 248-9. 

A 21-year-old male with a history of depression was diagnosed with psychosis, which were probably due to selfadministration of high doses of modafinil over a period of 16 months (from 400 to 1600 mg/d) [42 ]. 

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