Dependence, genetics

Peterson LE, Barnholtz JS, Page GP, King TM, de Andrade M, Amos Cl. A genome-wide search for susceptibility genes linked to alcohol dependence. Genet Epidemiol 1999 17(Suppl 1] S295—300. 

A Cbfal-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 13 1025-1036... 

Bonafe M, Olivieri F, Cavallone L, et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 2001 31 2357-2361. 

A number of inborn errors of metabolism— vitamin dependent genetic diseases— result from the inability... 

Rosenberg, L. E., 1970, Vitamin-dependent genetic disease. Hospital Practice, 5 59-66. 

These facts, and all the material we have previously examined on ontogenetic changes in the protein and enzyme spectrum, make it clear that the key to the understanding of the programming of biochemical development lies at the level of DNA-dependent genetic) RNA synthesis. 

The distribution between LDL and HDL choles terol depends mainly on genetic factors but can be... 

Gene Expression Systems. One of the potentials of genetic engineering of microbes is production of large amounts of recombinant proteias (12,13). This is not a trivial task. Each proteia is unique and the stabiUty of the proteia varies depending on the host. Thus it is not feasible to have a single omnipotent microbial host for the production of all recombinant proteias. Rather, several microbial hosts have to be studied. Expression vectors have to be tailored to the microbe of choice. 

Future Outlook for Pharmacologic Treatment of Abuse and Dependence. The importance of the psychosocial dimension ia predisposiag iadividuals toward substance use disorders and subsequentiy maintaining the disorder caimot be overestimated. Additionally, genetic influences have been found to exert an important influence on HabiUty for dmg abuse. A high comorbidity of psychiatric illnesses with substance use disorders further compHcates therapeutic iaterventions ia such patients (236). 

Chemical, or abiotic, transformations are an important fate of many pesticides. Such transformations are ubiquitous, occurring in either aqueous solution or sorbed to surfaces. Rates can vary dramatically depending on the reaction mechanism, chemical stmcture, and relative concentrations of such catalysts as protons, hydroxyl ions, transition metals, and clay particles. Chemical transformations can be genetically classified as hydrolytic, photolytic, or redox reactions (transfer of electrons). 

---