Deoxyribonucleic acid destroy

Deoxyribonucleic acids readily undergo hydrolysis whereby purine bases are removed to give a derived polynucleotide originally named thymic acid, but now often called apurinic acid. Hydrolysis may be carried out with dilute mineral acid, but recently apurinic acids have been prepared by fission at room temperature with an acidic, ion-exchange resin.236 Under carefully controlled conditions, removal of the purines can be performed quantitatively without destroying the polynucleotide nature of the material and without altering the inter-pyrimidine ratios of the original material.23 ... 

Atomic oxygen attacks and destroys enzymes and other protein molecules, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) molecules, and other essential biochemical molecules, interrupting... 

VVThen a beam of ionizing radiation hits living cells, important cell functions may be altered or destroyed. In particular, the replication mechanisms of the cell which are associated with their genetic material, deoxyribonucleic acid (DNA), are particularly radiosensitive. In order to appreciate fully the biological implications of this damage, further understanding at the chemical level is needed. For these reasons, we are undertaking a detailed study of the reactions of the primary reactive species in water (e aq,-OH) with nucleic acid derivatives. 

Deoxyribonucleic acid has been immobilized without chemical alteration by entrapment in agarose. The gel was either heated or dissolved in sodium perchlorate to destroy its secondary structure and then gelled in the presence of DNA by cooling or dialysis, respectively. Some rotational constraint of the DNA molecule was observed as evidenced by the binding constant obtained for the drug ethidium the nature of the constraint was discussed in terms of the known structure of agarose bihelices. 

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